Internalization and degradation of receptor-bound human choriogonadotropin in Leydig tumor cells. Fate of the hormone subunits.
M Ascoli - Journal of Biological Chemistry, 1982 - ASBMB
The studies presented herein were aimed at characterizing the pathway involved in the
internalization and degradation of human choriogonadotropin by cultured Leydig tumor
cells. A quick biochemical method that differentiates between the surface-bound and
internalized hormone was developed. Using this method and two hormone derivatives
labeled exclusively (with 125I) in the alpha or beta subunits, it was possible to follow the fate
of each hormone subunit during hormone binding, internalization, and degradation. The …
internalization and degradation of human choriogonadotropin by cultured Leydig tumor
cells. A quick biochemical method that differentiates between the surface-bound and
internalized hormone was developed. Using this method and two hormone derivatives
labeled exclusively (with 125I) in the alpha or beta subunits, it was possible to follow the fate
of each hormone subunit during hormone binding, internalization, and degradation. The …