[HTML][HTML] Involvement of G Protein-coupled Receptor Kinase 5 in Homologous Desensitization of the Thyrotropin Receptor (∗)
Y Nagayama, K Tanaka, T Hara, H Namba… - Journal of Biological …, 1996 - ASBMB
Homologous desensitization of G protein-coupled receptors involves agonist-dependent
phosphorylation of receptors by G protein-coupled receptor kinases (GRKs). To identify GRK
(s) that play a role in homologous desensitization of the thyrotropin (TSH) receptor, thyroid
cDNA was amplified by polymerase chain reaction using degenerate oligonucleotide
primers from highly conserved regions in GRK family. GRK5 is found in the predominant
isoform expressed in the thyroid. Rat GRK5 cDNA was then isolated, which encodes a 590 …
phosphorylation of receptors by G protein-coupled receptor kinases (GRKs). To identify GRK
(s) that play a role in homologous desensitization of the thyrotropin (TSH) receptor, thyroid
cDNA was amplified by polymerase chain reaction using degenerate oligonucleotide
primers from highly conserved regions in GRK family. GRK5 is found in the predominant
isoform expressed in the thyroid. Rat GRK5 cDNA was then isolated, which encodes a 590 …