Acitretin in the treatment of severe lichen sclerosus et atrophicus of the vulva: a double-blind, placebo-controlled study
MT Bousema, U Romppanen, JM Geiger… - Journal of the American …, 1994 - Elsevier
Background: Promising results have been reported from treatment with oral retinoids in
patients with severe lichen sclerosus et atrophicus (LSA) of the vulva. Objective: The aim of
our study was to determine the efficacy of acitretin (20 to 30 mg/day) for 16 weeks in LSA.
Methods: Seventy-eight patients were enrolled into a multicenter, randomized, placebo-
controlled, double-blind trial. The primary measure of efficacy was the “responder” rate
based on the assessment of characteristic clinical features of LSA of the vulva (pruritus …
patients with severe lichen sclerosus et atrophicus (LSA) of the vulva. Objective: The aim of
our study was to determine the efficacy of acitretin (20 to 30 mg/day) for 16 weeks in LSA.
Methods: Seventy-eight patients were enrolled into a multicenter, randomized, placebo-
controlled, double-blind trial. The primary measure of efficacy was the “responder” rate
based on the assessment of characteristic clinical features of LSA of the vulva (pruritus …