Multiple sclerosis and the HLA-D region: linkage and association studies
Inheritance patterns of multiple sclerosis (MS) in multiplex families suggest a complex
aetiology involving environmental and genetically determined components. The association
between the HLA class II DR15, DQ6, Dw2 haplotype and MS has been well documented in
patients with ancestral origins in Northern Europe. Conversely, linkage analysis of this
region in multiplex families, derived from a population base, has generated negative results.
Thus, given the Dw2 specificity association, evidence implicating this locus in disease …
aetiology involving environmental and genetically determined components. The association
between the HLA class II DR15, DQ6, Dw2 haplotype and MS has been well documented in
patients with ancestral origins in Northern Europe. Conversely, linkage analysis of this
region in multiplex families, derived from a population base, has generated negative results.
Thus, given the Dw2 specificity association, evidence implicating this locus in disease …