Catalytically active TYK2 is essential for interferon-β-mediated phosphorylation of STAT3 and interferon-α receptor-1 (IFNAR-1) but not for activation of …
MRS Rani, DW Leaman, Y Han, S Leung… - Journal of Biological …, 1999 - ASBMB
TYK2, a Janus kinase, plays both structural and catalytic roles in type I interferon (IFN)
signaling. We recently reported (Rani, MRS, Gauzzi, C., Pellegrini, S., Fish, E., Wei, T., and
Ransohoff, RM (1999) J. Biol. Chem. 274, 1891–1897) that catalytically active TYK2 was
necessary for IFN-β to induce the β-R1 gene. We now report IFN-β-mediated activation of
STATs and other components in U1 (TYK2-null) cell lines that were complemented with
kinase-negative (U1. KR930) or wild-type TYK2 (U1. wt). We found that IFN-β induced …
signaling. We recently reported (Rani, MRS, Gauzzi, C., Pellegrini, S., Fish, E., Wei, T., and
Ransohoff, RM (1999) J. Biol. Chem. 274, 1891–1897) that catalytically active TYK2 was
necessary for IFN-β to induce the β-R1 gene. We now report IFN-β-mediated activation of
STATs and other components in U1 (TYK2-null) cell lines that were complemented with
kinase-negative (U1. KR930) or wild-type TYK2 (U1. wt). We found that IFN-β induced …
