Experimental Pulmonary Eosinophilia in Mice by Ascaris suum Extract1• 2
M Nogami, M Suko, H Okudaira, T Miyamoto… - Am Rev Respir …, 1990 - atsjournals.org
M Nogami, M Suko, H Okudaira, T Miyamoto, J Shiga, M Ito, S Kasuya
Am Rev Respir Dis, 1990•atsjournals.orgThe transnasal administration of an extract of the parasite Ascaris suum (Asc) to C57BU6
mice for 3 wk produced marked eosinophilia in the bronchoalveolar lavage (BAL) fluid. This
pulmonary eosinophilia was not accompanied by blood eosinophilia. The oral
administration of cyclosporin, 50 mg/kg body weight, every other day significantly
suppressed the pulmonary eosinophilia.
mice for 3 wk produced marked eosinophilia in the bronchoalveolar lavage (BAL) fluid. This
pulmonary eosinophilia was not accompanied by blood eosinophilia. The oral
administration of cyclosporin, 50 mg/kg body weight, every other day significantly
suppressed the pulmonary eosinophilia.
Summary
The transnasal administration of an extract of the parasite Ascaris suum (Asc) to C57BU6 mice for 3 wk produced marked eosinophilia in the bronchoalveolar lavage (BAL) fluid. This pulmonary eosinophilia was not accompanied by blood eosinophilia. The oral administration of cyclosporin, 50 mg/kg body weight, every other day significantly suppressed the pulmonary eosinophilia.
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