A virion-specific inhibitory molecule with therapeutic potential for human immunodeficiency virus type 1.
Z Matsuda, X Yu, QC Yu, TH Lee… - Proceedings of the …, 1993 - National Acad Sciences
Z Matsuda, X Yu, QC Yu, TH Lee, M Essex
Proceedings of the National Academy of Sciences, 1993•National Acad SciencesA potential new approach for gene therapy against human immunodeficiency virus type 1
(HIV-1) infection is the design of a nonstructural gene-based virion-specific inhibitory
molecule that is packaged with virus to destroy its infectivity. We tested this approach for HIV-
1 by using Vpx, a virion-associated protein of HIV-2 and simian immunodeficiency virus. Vpx
was incorporated into HIV-1 virions and the resulting cell-free virus lost infectivity in CD4+
human T cells. This demonstrates the therapeutic potential of an accessory gene-based …
(HIV-1) infection is the design of a nonstructural gene-based virion-specific inhibitory
molecule that is packaged with virus to destroy its infectivity. We tested this approach for HIV-
1 by using Vpx, a virion-associated protein of HIV-2 and simian immunodeficiency virus. Vpx
was incorporated into HIV-1 virions and the resulting cell-free virus lost infectivity in CD4+
human T cells. This demonstrates the therapeutic potential of an accessory gene-based …
A potential new approach for gene therapy against human immunodeficiency virus type 1 (HIV-1) infection is the design of a nonstructural gene-based virion-specific inhibitory molecule that is packaged with virus to destroy its infectivity. We tested this approach for HIV-1 by using Vpx, a virion-associated protein of HIV-2 and simian immunodeficiency virus. Vpx was incorporated into HIV-1 virions and the resulting cell-free virus lost infectivity in CD4+ human T cells. This demonstrates the therapeutic potential of an accessory gene-based virion-specific inhibitory molecule. Vpx and its derivatives can be regarded as a new class of anti-HIV-1 molecule.
National Acad Sciences