Cation–π interactions in ligand recognition and catalysis
N Zacharias, DA Dougherty - Trends in pharmacological sciences, 2002 - cell.com
N Zacharias, DA Dougherty
Trends in pharmacological sciences, 2002•cell.comThe cation–π interaction is a potent, general noncovalent binding force that is observed in a
wide range of biological contexts. Here, we present an overview of well documented cases
in which a cation–π interaction makes an important contribution to small-molecule
recognition at a protein binding site. From these and other studies it is clear that, in addition
to the hydrophobic effect, hydrogen bonding and ion pairing, the cation–π interaction must
be considered when evaluating drug–receptor interactions.
wide range of biological contexts. Here, we present an overview of well documented cases
in which a cation–π interaction makes an important contribution to small-molecule
recognition at a protein binding site. From these and other studies it is clear that, in addition
to the hydrophobic effect, hydrogen bonding and ion pairing, the cation–π interaction must
be considered when evaluating drug–receptor interactions.
Abstract
The cation–π interaction is a potent, general noncovalent binding force that is observed in a wide range of biological contexts. Here, we present an overview of well documented cases in which a cation–π interaction makes an important contribution to small-molecule recognition at a protein binding site. From these and other studies it is clear that, in addition to the hydrophobic effect, hydrogen bonding and ion pairing, the cation–π interaction must be considered when evaluating drug–receptor interactions.
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