[HTML][HTML] Molecular Cloning and Functional Analysis of a Novel P2 Nucleotide Receptor (∗)
K Chang, K Hanaoka, M Kumada, Y Takuwa - Journal of Biological …, 1995 - ASBMB
The cDNA encoding a novel P 2 receptor was isolated from rat aortic smooth muscle cell
library and functionally characterized. The cloned P 2 receptor exhibits structural features
characteristic of the G protein-coupled receptor family and shows 44 and 38% amino acid
identity with previously cloned rat P 2U and chicken P 2Y receptors, respectively. The cloned
P 2 receptor is functionally coupled to phospholipase C but not to adenylate cyclase in C6
rat glioma cells transfected with the cloned P 2 expression vector. The rank order of agonist …
library and functionally characterized. The cloned P 2 receptor exhibits structural features
characteristic of the G protein-coupled receptor family and shows 44 and 38% amino acid
identity with previously cloned rat P 2U and chicken P 2Y receptors, respectively. The cloned
P 2 receptor is functionally coupled to phospholipase C but not to adenylate cyclase in C6
rat glioma cells transfected with the cloned P 2 expression vector. The rank order of agonist …