Prolactin and systemic lupus erythematosus: prolactin secretion by SLE lymphocytes and proliferative (autocrine) activity
MA Gutierrez, JF Molina, LJ Jara, ML Cuellar… - Lupus, 1995 - journals.sagepub.com
Accumulated evidence suggests that prolactin (PRL) is an important immunoregulator and
might have a role in the pathogenesis of systemic lupus erythematosus (SLE). Moreover, a
PRL-like molecule is secreted by normal human lymphocytes and acts as an autocrine
growth factor for lymphoproliferation. The objective of this study was to explore the PRL-like
peptide production by peripheral blood mononuclear cells (PBMC) from patients with SLE.
We investigated the PRL secretion by PBMC from six female SLE patients and nine normal …
might have a role in the pathogenesis of systemic lupus erythematosus (SLE). Moreover, a
PRL-like molecule is secreted by normal human lymphocytes and acts as an autocrine
growth factor for lymphoproliferation. The objective of this study was to explore the PRL-like
peptide production by peripheral blood mononuclear cells (PBMC) from patients with SLE.
We investigated the PRL secretion by PBMC from six female SLE patients and nine normal …
Prolactin and systemic lupus erythematosus.
RW McMurray - Annales de medecine interne, 1996 - europepmc.org
Prolactin in a pituitary peptide hormone which is immunomodulatory. Increased serum
prolactin concentrations accelerate autoimmunity in the NZB x NZW F1 mouse model of
SLE. Some patients with SLE are hyperprolactinemic and, in cross-sectional and
longitudinal studies, serum prolactin has been associated with or correlated to lupus
disease activity. Suppression of physiologic levels of prolactin by bromocriptine
administration was associated with improvement in SLE in a preliminary study. While …
prolactin concentrations accelerate autoimmunity in the NZB x NZW F1 mouse model of
SLE. Some patients with SLE are hyperprolactinemic and, in cross-sectional and
longitudinal studies, serum prolactin has been associated with or correlated to lupus
disease activity. Suppression of physiologic levels of prolactin by bromocriptine
administration was associated with improvement in SLE in a preliminary study. While …
