Identification of residues of CXCR4 critical for human immunodeficiency virus coreceptor and chemokine receptor activities
A Brelot, N Heveker, M Montes, M Alizon - Journal of Biological Chemistry, 2000 - ASBMB
CXCR4 is a G-coupled receptor for the stromal cell-derived factor (SDF-1) chemokine, and a
CD4-associated human immunodeficiency virus type 1 (HIV-1) coreceptor. These functions
were studied in a panel of CXCR4 mutants bearing deletions in the NH 2-terminal
extracellular domain (NT) or substitutions in the NT, the extracellular loops (ECL), or the
transmembrane domains (TMs). The coreceptor activity of CXCR4 was markedly impaired
by mutations of two Tyr residues in NT (Y7A/Y12A) or at a single Asp residue in ECL2 …
CD4-associated human immunodeficiency virus type 1 (HIV-1) coreceptor. These functions
were studied in a panel of CXCR4 mutants bearing deletions in the NH 2-terminal
extracellular domain (NT) or substitutions in the NT, the extracellular loops (ECL), or the
transmembrane domains (TMs). The coreceptor activity of CXCR4 was markedly impaired
by mutations of two Tyr residues in NT (Y7A/Y12A) or at a single Asp residue in ECL2 …
