Functional subsets within clonally expanded CD8+ memory T cells in elderly humans
WD Chamberlain, MT Falta, BL Kotzin - Clinical Immunology, 2000 - Elsevier
With advancing age, healthy humans frequently demonstrate large clonal expansions of
CD8+ T cells in the peripheral blood, which persist for long periods of time and appear to be
maintained as a population of memory cells. We studied nine large T cell clones in five
elderly individuals. We noted that in most cases the expanded clones were dominated by
cells that did not express CD28, a pivotal molecule in T cell activation, and these clones
proliferated poorly in culture. However, nearly all of the clonal expansions had CD28+ …
CD8+ T cells in the peripheral blood, which persist for long periods of time and appear to be
maintained as a population of memory cells. We studied nine large T cell clones in five
elderly individuals. We noted that in most cases the expanded clones were dominated by
cells that did not express CD28, a pivotal molecule in T cell activation, and these clones
proliferated poorly in culture. However, nearly all of the clonal expansions had CD28+ …
