Human smooth muscle cells were used to investigate the antiproliferative activities of
sulfated carbohydrates. The antiproliferative potencies of coarse heparin fractions prepared
by ultrafiltration increased with the mean molecular-weight, whereas the anticoagulant
activities of a high-molecular-weight fraction had submaximal values. Furthermore, the
dependence of antiproliferative activity on sulfate content is discussed. Carboxyl-reduction
of heparin abolished both antiproliferative and anticoagulant activities. Sulfation of this …