Hepatocyte growth factor induces differentiation of adult rat bone marrow cells into a hepatocyte lineage in vitro
SH Oh, M Miyazaki, H Kouchi, Y Inoue… - Biochemical and …, 2000 - Elsevier
SH Oh, M Miyazaki, H Kouchi, Y Inoue, M Sakaguchi, T Tsuji, N Shima, K Higashio…
Biochemical and Biophysical Research Communications, 2000•ElsevierBone marrow (BM) cells originally include alpha-fetoprotein (AFP)-and c-Met [a receptor for
hepatocyte growth factor (HGF)]-expressing cells. In vitro treatment of BM cells with HGF
induced albumin-expressing hepatocyte-like cells. Furthermore, those hepatocyte-like cells
expressed cytokeratins 8 and 18, which are typically expressed in normal adult hepatocytes.
These findings demonstrate that BM cells include AFP-expressing hepatic progenitor cells
that can be differentiated into hepatocytes by HGF in culture, indicating that such cultures …
hepatocyte growth factor (HGF)]-expressing cells. In vitro treatment of BM cells with HGF
induced albumin-expressing hepatocyte-like cells. Furthermore, those hepatocyte-like cells
expressed cytokeratins 8 and 18, which are typically expressed in normal adult hepatocytes.
These findings demonstrate that BM cells include AFP-expressing hepatic progenitor cells
that can be differentiated into hepatocytes by HGF in culture, indicating that such cultures …
Bone marrow (BM) cells originally include alpha-fetoprotein (AFP)- and c-Met [a receptor for hepatocyte growth factor (HGF)]-expressing cells. In vitro treatment of BM cells with HGF induced albumin-expressing hepatocyte-like cells. Furthermore, those hepatocyte-like cells expressed cytokeratins 8 and 18, which are typically expressed in normal adult hepatocytes. These findings demonstrate that BM cells include AFP-expressing hepatic progenitor cells that can be differentiated into hepatocytes by HGF in culture, indicating that such cultures are useful resources for cell transplantation therapy for liver diseases.
Elsevier
