[HTML][HTML] Cloning and Characterization of PHIP, a Novel Insulin Receptor Substrate-1 Pleckstrin Homology DomainInteracting Protein
J Farhang-Fallah, X Yin, G Trentin, AM Cheng… - Journal of Biological …, 2000 - ASBMB
Insulin receptor substrate-1 (IRS-1) protein is a major substrate of the insulin receptor
tyrosine kinase and is essential for transducing many of the biological effects of insulin
including mitogenesis, gene expression, and glucose transport. The N terminus of IRS-1
contains a pleckstrin homology (PH) domain that is critical for recognition and subsequent
phosphorylation of IRS-1 by the activated insulin receptor. Here we report the isolation of a
novel protein, PHIP (PH-interactingprotein), which selectively binds to the PH domain of IRS …
tyrosine kinase and is essential for transducing many of the biological effects of insulin
including mitogenesis, gene expression, and glucose transport. The N terminus of IRS-1
contains a pleckstrin homology (PH) domain that is critical for recognition and subsequent
phosphorylation of IRS-1 by the activated insulin receptor. Here we report the isolation of a
novel protein, PHIP (PH-interactingprotein), which selectively binds to the PH domain of IRS …