Expression of GLUT-2 antisense RNA in beta cells of transgenic mice leads to diabetes.
A Valera, G Solanes, J Fernández-Alvarez… - Journal of Biological …, 1994 - ASBMB
An insulin response to glucose is required to correct hyperglycemia. Two proteins, the
glucose transporter GLUT-2 and the glucose-phosphorylating enzyme glucokinase, have
been implicated in the control of glucose metabolism in beta cells. To study the role of
glucose transporter GLUT-2 in the regulation of insulin secretion and in the development of
diabetes mellitus, we have obtained transgenic mice expressing high levels of GLUT-2
antisense RNA in beta cells. Western blot analysis showed an 80% reduction in GLUT-2 …
glucose transporter GLUT-2 and the glucose-phosphorylating enzyme glucokinase, have
been implicated in the control of glucose metabolism in beta cells. To study the role of
glucose transporter GLUT-2 in the regulation of insulin secretion and in the development of
diabetes mellitus, we have obtained transgenic mice expressing high levels of GLUT-2
antisense RNA in beta cells. Western blot analysis showed an 80% reduction in GLUT-2 …
