Cellular adhesion molecules (CAMs) play an essential role in tethering circulating
leukocytes to the vascular endothelium at sites of inflammation. They are also instrumental
in enabling leukocytes to transmigrate from blood vessels into adjacent inflamed tissues. In
the absence of signals to stimulate expression of CAMs, the adhesive forces between
leukocytes and the vascular endothelium are below the threshold level required to tether
leukocytes. Research in the last decade has shown that several cytokines, including tumour …