[HTML][HTML] Protein kinase B/Akt mediates effects of insulin on hepatic insulin-like growth factor-binding protein-1 gene expression through a conserved insulin response …
Insulin regulates the expression of multiple hepatic genes through a conserved insulin
response sequence (IRS)(CAAAAC/TAA) by an as yet undetermined mechanism. Protein
kinase B/Akt (PKB/Akt), a member of the PKA/PKC serine/threonine kinase family, functions
downstream from phosphatidylinositol 3′-kinase (PI3K) in mediating effects of insulin on
glucose transport and glycogen synthesis. We asked whether PKB/Akt mediates sequence-
specific effects of insulin on hepatic gene expression using the model of the insulin-like …
response sequence (IRS)(CAAAAC/TAA) by an as yet undetermined mechanism. Protein
kinase B/Akt (PKB/Akt), a member of the PKA/PKC serine/threonine kinase family, functions
downstream from phosphatidylinositol 3′-kinase (PI3K) in mediating effects of insulin on
glucose transport and glycogen synthesis. We asked whether PKB/Akt mediates sequence-
specific effects of insulin on hepatic gene expression using the model of the insulin-like …
