Liver and kidney metabolism during prolonged starvation
OE Owen, P Felig, AP Morgan… - The Journal of …, 1969 - Am Soc Clin Investig
OE Owen, P Felig, AP Morgan, J Wahren, GF Cahill
The Journal of clinical investigation, 1969•Am Soc Clin InvestigThis study quantifies the concentrations of circulating insulin, growth hormone, glucose, free
fatty acids, glycerol, β-hydroxybutyrate, acetoacetate, and alpha amino nitrogen in 11 obese
subjects during prolonged starvation. The sites and estimated rates of gluconeogenesis and
ketogenesis after 5-6 wk of fasting were investigated in five of the subjects. Blood glucose
and insulin concentrations fell acutely during the 1st 3 days of fasting, and alpha amino
nitrogen after 17 days. The concentration of free fatty acids, β-hydroxybutyrate, and …
fatty acids, glycerol, β-hydroxybutyrate, acetoacetate, and alpha amino nitrogen in 11 obese
subjects during prolonged starvation. The sites and estimated rates of gluconeogenesis and
ketogenesis after 5-6 wk of fasting were investigated in five of the subjects. Blood glucose
and insulin concentrations fell acutely during the 1st 3 days of fasting, and alpha amino
nitrogen after 17 days. The concentration of free fatty acids, β-hydroxybutyrate, and …
This study quantifies the concentrations of circulating insulin, growth hormone, glucose, free fatty acids, glycerol, β-hydroxybutyrate, acetoacetate, and alpha amino nitrogen in 11 obese subjects during prolonged starvation. The sites and estimated rates of gluconeogenesis and ketogenesis after 5-6 wk of fasting were investigated in five of the subjects.
Blood glucose and insulin concentrations fell acutely during the 1st 3 days of fasting, and alpha amino nitrogen after 17 days. The concentration of free fatty acids, β-hydroxybutyrate, and acetoacetate did not reach a plateau until after 17 days.
Estimated glucose production at 5-6 wk of starvation is reduced to approximately 86 g/24 hr. Of this amount the liver contributes about one-half and the kidney the remainder. Approximately all of the lactate, pyruvate, glycerol, and amino acid carbons which are removed by liver and kidney are converted into glucose, as evidenced by substrate balances across these organs.
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The Journal of Clinical Investigation