The HHQK domain of β-amyloid provides a structural basis for the immunopathology of Alzheimer's disease
D Giulian, LJ Haverkamp, J Yu, W Karshin… - Journal of Biological …, 1998 - ASBMB
The β-amyloid peptide 1–42 (Aβ1–42), a major component of neuritic and core plaques
found in Alzheimer's disease, activates microglia to kill neurons. Selective modifications of
amino acids near the N terminus of Aβ showed that residues 13–16, the HHQK domain, bind
to microglial cells. This same cluster of basic amino acids is also known as a domain with
high binding affinity for heparan sulfate. Both Aβ binding to microglia and Aβ induction of
microglial killing of neurons were sensitive to heparitinase cleavage and to competition with …
found in Alzheimer's disease, activates microglia to kill neurons. Selective modifications of
amino acids near the N terminus of Aβ showed that residues 13–16, the HHQK domain, bind
to microglial cells. This same cluster of basic amino acids is also known as a domain with
high binding affinity for heparan sulfate. Both Aβ binding to microglia and Aβ induction of
microglial killing of neurons were sensitive to heparitinase cleavage and to competition with …
